By N M Hooper; Humana Press

ISBN-10: 0585395071

ISBN-13: 9780585395074

ISBN-10: 0896037371

ISBN-13: 9780896037373

ISBN-10: 1592591957

ISBN-13: 9781592591954

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The only current example of a trial that used a patient cohort more impaired than the standard defined by the MMSE range of 10–26 was the Sano et al. study (8). The entry criteria for that study required that patients were to be rated as a Clinical Dementia Rating (CDR) (9) stage of 2. A CDR rating of 2 is consistent with a moderate stage of dementia severity, with substantially impaired memory, substantially impaired daily living skills, and some decline in ability to carry out tasks such as dressing and toileting independently.

2. Functions and Pathogenesis of the Presenilins and Their Mutated Isoforms A potential clue to the function of the presenilins comes from the recognition of strong homology of PS1 to Caenorrhabditis elegans proteins sel-12 and spe-4. PS-1 shares 60% homology with sel-12 (66), which has been demonstrated to facilitate Lin-12-mediated signaling. In mammals, lin-12 homologues are members of the Notch family of receptors known as Notch1, Notch2, and Notch3. The molecular homology of both presenilins to sel-12 implies a role in the signal transduction mechanisms mediated by lin-12/Notch, thus they may play a direct role in the cell fate decisions mediated by these same genes.

And Gergem, A. C. M. (1993) Use of twin cohorts for research in Alzheimer’s disease. Neurology 43, 261–267. 3. Heston, L. , Mastri, A. , and White, J. (1981) Dementia of the Alzheimer type. Clinical genetics, natural history and associated conditions. Arch. Gen. Psych. 112, 227–239. 4. Thal, L. , and Klauber, M. R. (1988) Dementia: characteristics of a referral population and factors associated with progression. Neurology 38, 1083–1090. 5. , Tanja, T. , et al. (1989) History of dementia and Parkinson’s disease in first degree relatives of patients with Alzheimer’s disease.

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Alzheimer's disease : methods and protocols by N M Hooper; Humana Press

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